The method's developers have used it to study how ageing might alter the way that proteins in the nucleus interact with chromosomes, revealing changes that could suppress gene activity.
This paper is really extraordinary. The phenomenal technique allows for high-resolution imaging of both DNA and proteins within cells without their contents being disrupted, providing groundbreaking insights.
Researchers are studying how DNA is wound around proteins in the cell nuclei and how gene locations can influence their activity, which is a vital area of exploration.
We can think of DNA as a linear string of information that has to be organized inside a 5-micron-sized cell nucleus. Understanding this folding is crucial.
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