The study shows that adipocytes retain a memory of obesity through epigenetic changes that persist after weight loss, making it easier to gain weight back.
Researchers found that the cellular memory of obesity creates a physiological predisposition to regain weight, complicating the narrative that weight regain is solely about willpower.
The findings suggest that the struggle against obesity is not merely a problem of choice, but is deeply rooted in biological mechanisms that underpin weight regulation.
Ferdinand von Meyenn stated, 'The challenges of maintaining weight loss are driven by biological phenomena, not just personal determination or effort'.
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