Victor Ambros and Gary Ruvkun's groundbreaking discovery of microRNA has transformed our understanding of gene regulation, enabling potential early tests for devastating diseases like cancer.
Their pioneering work revealed that despite identical genetic information, cells utilize this code in diverse ways, significantly impacting the body’s functions and leading to serious diseases when gene regulation fails.
The Nobel Assembly highlighted that their work on microRNA introduced a new principle of gene regulation crucial for multicellular organisms, such as humans, elucidating how genes function in health and disease.
Ruvkun expressed surprise and enthusiasm upon receiving the Nobel Prize, stating, 'It's a big deal. It's a big one. It's an earthquake,' indicating the magnitude of their scientific achievement.
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