Microglia are not necessarily misfunctioning when their mitochondria are impaired based purely on proliferation, at least not in the central nervous system. The surprising discovery was that while microglia can still proliferate to a certain extent without mitochondria, the client cells are not as effective at responding to demyelinating injuries.
Mitochondria play a crucial role in how microglial cells respond to demyelinating injuries, although they do not significantly impact other neurological diseases or functions. This new comprehension could pave the way for potential therapeutic interventions targeting microglial function in treating central nervous system disorders.
The study revealed an intriguing connection between microglial function, mitochondria, and their role in immune responses, especially concerning demyelinating injuries within the central nervous system. While microglia support brain development and maintenance, their relationship with mitochondrial function is key in aiding recovery post-injury.
Collection
[
|
...
]