Recent research led by Navdeep Chandel, PhD, reveals that mitochondria play a crucial role in regulating the immune response via specific signaling pathways. The study emphasizes the potential of therapies aimed at enhancing mitochondrial function in immune cells to treat various inflammation-related conditions, including inflammatory bowel disease and sepsis. Key findings indicate that reactive oxygen species produced by mitochondrial complex III are essential for macrophages to produce IL-10, an anti-inflammatory protein that helps regulate immune responses and combat excess inflammation.
"Therapies aimed at improving mitochondrial activity could benefit inflammatory diseases such as inflammatory bowel disease, sepsis, and chronic infections by enhancing the immune system's ability to regulate inflammation."
"Using bulk-RNA sequencing to study mice with macrophages deficient in mitochondria ETC complex III, the scientists discovered that a type of reactive oxygen species (ROS) called superoxide is critical for macrophages to release IL-10."
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