This study lays the translational groundwork for a clinical trial of anti-TIM3 therapy in pediatric patients with pilocytic astrocytoma who are in dire need of therapeutic strategies.
This is a disease where stability of the tumor is defined as success. We're not able to eliminate these tumors with either chemotherapy or radiation.
Better therapies include new precision medicine strategies, as repurposing current immunotherapies traditionally given to adult patients in these pediatric patients has been historically unsuccessful.
Patients with tumors in areas of the brain that can't be accessed with surgery are in urgent need of alternative treatment options in addition to standard chemotherapy and radiation.
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