A recent study has identified 64 genes that influence the aging of the brain, providing significant insights into genetic factors behind cognitive decline. Published in Science Advances, this research analyzed brain scans from over 38,000 individuals and focused on the brain age gap (BAG). The team developed a list of potential drug compounds that could target these genes, indicating new avenues for anti-aging treatments. While promising, researchers emphasize that further studies are essential before practical applications can be established.
The findings are significant because they could pave the way for new treatments to keep the brain healthier longer, says Agustín Ibánez.
To narrow down which of the BAG-linked genes are good targets for new or repurposed drugs, the authors combined their analyses with activity data for 2,682 genes in blood cells and 2,915 genes in brain tissue.
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