Sam Berns' story inspires us to look beyond the limitations of genetics; his progeria shows how one letter gene mutation affects aging, leading to rapid decline.
The discovery of the genetic cause of progeria led to an understanding of the need for precise editing technologies. We must move towards a 'find and replace' method.
CRISPR's FDA approval for sickle cell disease showcases the progress in gene editing, but for conditions like progeria, different techniques are required to directly correct mutations.
Future therapies for progeria must focus on repairing the specific gene mutation directly at the point of damage, a challenging but essential next step in treatment.
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