New England's defense is struggling, having allowed 30 points to the Cardinals, making them vulnerable against the high-scoring Bills offense led by MVP frontrunner Josh Allen.
The Bills are averaging 41.6 points and 458.6 total yards of offense over the last three weeks, setting the stage for a potentially lopsided game against the Patriots.
Betting odds reflect the grim outlook for New England, with several oddsmakers listing them as 14-point underdogs as they prepare to face the Bills.
The Patriots have been flexed to a higher timeslot against the Bills, highlighting the importance of the game despite New England's struggling season.
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