Anfernee Jennings, a key starter on the Patriots' defensive edge, has been ruled out for Week 4 due to a shoulder injury, impacting an already depleted defense.
With Jennings out, the Patriots may turn to defensive linemen like Keion White and Deatrich Wise Jr. or off-ball linebackers Tavai and McMillan to fill the gap.
The Patriots will play without not just Jennings but also Ja'Whaun Bentley and Christian Barmore, further hampering their defensive capabilities against a strong 49ers offense.
While down several players, the team received good news regarding the offensive line with both Caedan Wallace and Sidy Sow cleared to play.
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