The New England Patriots will face significant challenges against the San Francisco 49ers due to key player injuries, including offensive tackle Vederian Lowe and others being ruled out.
Head coach Jerod Mayo now travels to Santa Clara without major components of his offensive line, which has been underperforming after a 24-3 loss to the New York Jets.
The Patriots are left with several players listed as questionable, raising concerns about their ability to compete, particularly in defensive and offensive positions.
With injuries affecting both the offensive and defensive lines, the Patriots will need to adapt quickly as they approach a tough matchup against the reigning NFC champions.
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