"Bowen: 49ers quarterback Brock Purdy will have defined reads versus the Eagles' split-safety coverages. That's the play-action throws in Shanahan's game plan, plus the concepts designed to lift the safeties and create middle-of-the-field voids. Christian McCaffrey will see volume as a dual-threat option, too, and I like this run game matchup. Best bet: McCaffrey OVER 57.5 rushing yards (-111). McCaffrey has topped the 70-yard rushing mark in five of his past seven games, with 20 or more carries in five of his past six."
"Bowen: Philly wants to establish a run game identity with Saquon Barkley. The Eagles need more movement up front from the offensive front here. Plus, they will also look to take their shots down the field to A.J. Brown and DeVonta Smith. They can use isolation throws from the slot and boundary alignments, while Jalen Hurts will have to make some plays outside of the pocket. Best bet: Brown OVER 5.5 receptions (-105). Brown has at least six receptions in three of his past five games."
The matchup pits Kyle Shanahan's play-action and safety-manipulating concepts against Vic Fangio's defensive schemes. Brock Purdy will face split-safety coverages with defined reads while play-action and middle-of-the-field concepts aim to create voids. Christian McCaffrey projects heavy volume as a dual-threat runner and receiver, with a favorable run-game matchup versus Philadelphia. Philadelphia looks to establish a run identity with Saquon Barkley, create movement up front, and attack downfield to A.J. Brown and DeVonta Smith. Jalen Hurts will need to extend plays outside the pocket. Key bets include McCaffrey rushing yards OVER 57.5 and Brown receptions OVER 5.5.
Read at ESPN.com
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