The driver of the car involved in the collision on Blanchardstown Road North has yet to come forward, prompting Gardaí to launch an appeal for witnesses.
A female in her 30s was pronounced dead at the scene of the road incident, while a male in his 30s was hospitalized with serious injuries.
Local diversions have been set up as the road is closed for forensic examination, with investigations ongoing into the circumstances of the collision.
Gardaí are urging anyone who witnessed the collision or has relevant camera footage from the area to assist with their investigation.
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