The incorporation of histone variants such as H2A.Z plays a crucial role in nucleosome dynamics, influencing DNA repair and transcriptional regulation, as evidenced by the unique functions of the SWR1 and INO80 complexes in nucleosome remodeling.
SWR1 and INO80, despite their similarities, engage nucleosomes differently—SWR1 specifically catalyzes the exchange of H2A-H2B dimers for Htz1, showcasing its specialized function in chromatin dynamics.
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