The assembly of transcription factor (TF) combinations on gene regulatory elements like enhancers is crucial for achieving cell-type-specific gene expression and cellular reprogramming.
Pioneer transcription factors can access closed chromatin by recognizing motifs on mononucleosomes, facilitating the entry and binding of non-pioneer transcription factors to target genes.
Overexpression of unique combinations of TFs in mouse embryonic fibroblasts leads to distinct cell fates, showcasing the potential for specific reprogramming to induced pluripotent stem cells.
Combinatorial functions of TFs in cellular reprogramming highlight the importance of multi-motif patterns in nucleosome arrangements for targeting cell-type-specific enhancers.
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