#transcription-factors

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#t-cell-exhaustion #viral-infection #cancer-therapy #immunology #neocortical-excitatory-neurons
Cancer
fromNews Center
2 weeks ago

Transcription Factors Form Continuous 'Circuit' That Regulates T-cell Exhaustion - News Center

Two transcription factors regulate T-cell exhaustion and migration, impacting therapeutic strategies for infections and cancer.
fromNature
1 month ago

Adaptive evolution of gene regulatory networks in mammalian neocortex - Nature

To characterize CREs and TFs for neocortical ExNs, we used Arpp21-Gfp or Fezf2-Gfp transgenic mice and enriched GFP-expressing neocortical upper layer (L2-4) intratelencephalic (IT) neurons or deep layer (L5-6) predominantly extratelencephalic (ET) neurons, respectively, from neonatal mice (postnatal day (PD) 0), an age at which neocortical ExN identity and connectivity are established.
Roam Research
Medicine
fromNature
2 months ago

Atlas-guided discovery of transcription factors for T cell programming - Nature

Transcription factors determine CD8+ T cell states; identifying TFs that promote tissue-resident memory versus terminal exhaustion enables engineering of more effective adoptive T cell therapies.
OMG science
fromNature
2 months ago

Regulatory grammar in human promoters uncovered by MPRA-based deep learning - Nature

Massively parallel reporter assays provide cell-type-specific causal training data enabling more direct inference of DNA sequence effects on promoter activity than epigenomic maps.
fromenglish.elpais.com
9 months ago

Searching for an Alzheimer's cure in a chicken's eye

Many medical breakthroughs, whose benefits are easy for anyone to grasp, begin with scientists asking questions that are difficult for most people to understand.
Alternative medicine
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