Isaac Guerendo's rushing yards prop is set at 65.5 yards, significantly higher than his season average of 27.2 yards per game, suggesting a challenging matchup.
Despite averaging only 27.2 rushing yards, Guerendo has exceeded the 65.5 yards mark in three of his 11 games this season, highlighting the risk in betting on him.
Considering the Detroit Lions' defense ranks fourth against the run, yielding only 98.5 yards per game, betting on Guerendo's rushing over may not be prudent.
The 49ers have the eighth-ranked passing offense and are likely to exploit the Lions' weak pass defense, shifting the focus away from Guerendo's rushing potential.
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