The study introduces a biocatalytic method for stereoselective nucleophilic aromatic substitutions, presenting significant advancements in efficiency and selectivity over traditional techniques. This engineered enzyme, SNAr1.3, showcases a 160-fold improvement in performance, revealing its potential for diverse applications in chemical synthesis.
In conventional SNAr processes, selectivity control is limited due to the reliance on harsh conditions. Our findings demonstrate that engineered enzymes can facilitate these reactions under milder settings while maintaining exceptional stereocontrol, thus offering a greener alternative for synthetic chemists.
#biocatalysis #stereoselective-chemistry #nucleophilic-aromatic-substitution #chemical-synthesis #enzyme-engineering
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