Carbon-based frameworks provide the foundation for organic molecules, making the efficient construction of C-C bonds crucial in organic synthesis, spurring advances in cross-electrophile coupling.
Cross-electrophile coupling reactions (XECs) eliminate the need for organometallic reagents by directly linking two electrophilic partners, demonstrating efficiency and potentially reducing waste.
The formation of C(sp3)-C(sp3) bonds via XECs is challenging but essential, particularly since increased C(sp3) content in drug candidates correlates with clinical success.
Transition-metal-free methods for C(sp3)-C(sp3) XECs are sought to minimize waste and metal contamination, addressing economic and environmental concerns in organic synthesis.
#organic-synthesis #cross-coupling-reactions #c-c-bond-formation #transition-metals #drug-development
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