Post-translational modifications (PTMs) of histones regulate various DNA-templated processes, with specific types influencing chromatin structure and transcriptional activity relevant to cell fate.
We discovered a new class of histone PTM, where neurotransmitters like serotonin and dopamine can attach to glutamine, affecting neural transcription and cell behavior.
Monoaminylations on H3Q5 enhance the recruitment of the transcription factor TFIID and inhibit demethylases, crucial for regulating transcription during neural programming.
Accumulation of dopaminylation during drug abstinence may contribute to persistent transcriptional changes that increase vulnerability to relapse, indicating a role in addiction.
Collection
[
|
...
]