#transcription-regulation

[ follow ]
OMG science
fromNature
1 week ago

Can a mouse be cloned indefinitely? Decades-long experiment has answers

Asexual reproduction in mice is unsustainable due to accumulating mutations, limiting the potential for successful cloning.
Science
fromNature
2 weeks ago

Synthetic circuits for cell ratio control - Nature

Synthetic biology enables artificial cell differentiation and division of labor by engineering genetic and epigenetic circuits that mimic natural stem cell asymmetric division processes.
Science
fromwww.nature.com
2 weeks ago

Molecular basis of oocyte cytoplasmic lattice assembly

Cryo-EM reveals the cytoplasmic lattice in mammalian oocytes comprises repeating U-shaped basket and adapter ring units with 14 protein subunits, essential for oocyte maturation and embryonic development.
Science
fromNature
3 weeks ago

The dynamic basis of G-protein recognition and activation by a GPCR - Nature

NTSR1 receptor dynamically accommodates different G-protein subtypes through intracellular rearrangements, with GDP/GTP binding triggering G-protein dissociation through stepwise remodeling of switch regions.
fromwww.nature.com
1 month ago
Science

Genetically encoded assembly recorder temporally resolves cellular history

GEMINI is an intracellular recording platform using designed protein assemblies to capture cellular activity history with hour-level temporal precision through fluorescent tree-ring patterns.
Science
fromNature
1 month ago

DICER cleavage fidelity is governed by 5-end binding pockets - Nature

DICER is a conserved RNase III enzyme that processes precursor microRNAs and double-stranded RNAs into small regulatory RNAs through precise 5' and 3' end counting mechanisms.
Medicine
fromNature
1 month ago

Atlas-guided discovery of transcription factors for T cell programming - Nature

Transcription factors determine CD8+ T cell states; identifying TFs that promote tissue-resident memory versus terminal exhaustion enables engineering of more effective adoptive T cell therapies.
OMG science
fromNature
1 month ago

Regulatory grammar in human promoters uncovered by MPRA-based deep learning - Nature

Massively parallel reporter assays provide cell-type-specific causal training data enabling more direct inference of DNA sequence effects on promoter activity than epigenomic maps.
fromNews Center
1 month ago

AI Model May Improve RNA Sequencing Research - News Center

Scientists in the laboratory of Rendong Yang, PhD, associate professor of Urology, have developed a new large language model that can interpret transcriptomic data in cancer cell lines more accurately than conventional approaches, as detailed in a recent study published in Nature Communications. Long-read RNA sequencing technologies have transformed transcriptomics research by detecting complex RNA splicing and gene fusion events that have often been missed by conventional short-read RNA-sequencing methods.
Cancer
Philosophy
fromAeon
2 months ago

Groundbreaking visuals capture how our bodies repair damaged DNA | Aeon Videos

Drew Berry creates striking biomedical animations that visualize microscopic biological processes like DNA repair, revealing intricate evolution-shaped cellular mechanisms.
Science
fromNews Center
2 months ago

New Underlying Mechanisms May Support Proper Transcriptional Regulation and Improve - News Center

New mechanisms controlling transcription initiation and elongation involving BET family proteins were identified, revealing pathways that could enable improved targeted therapies for diseases including cancer.
Science
fromwww.nature.com
2 months ago

Scalable and multiplexed recorders of gene regulation dynamics across weeks

CytoTape enables multiplexed, genetically encoded, spatiotemporally scalable recording of gene regulation dynamics in single cells for up to three weeks with minute-scale resolution.
Science
fromNature
2 months ago

An expanded registry of candidate cis-regulatory elements - Nature

The cCRE registry expanded to 2.37 million human and 967,000 mouse elements and integrates functional characterization for over 97% of human cCREs.
Science
fromNews Center
2 months ago

Understanding the Link Between Nucleotide Metabolism and Chromatin Assembly - News Center

PRPS enzymes coordinate nucleotide synthesis and early histone maturation, synchronizing DNA replication and chromatin assembly through dual metabolic and regulatory roles.
Science
fromNews Center
2 months ago

New Underlying Mechanisms May Support Proper Transcriptional Regulation and Improve Targeted Therapies - News Center

BET proteins, particularly BRD4, regulate transcription initiation and elongation independently of bromodomains, with implications for targeted therapeutic development.
fromwww.nature.com
2 months ago

Author Correction: Nutrient-sensing nuclear receptors coordinate autophagy

In the originally published version of this article, Extended Data Fig. 4 contained inadvertent duplications introduced during figure assembly: panel 4c (the bottom of the second column) erroneously reused images from panel 4a (the bottom of the third column); panel 4c (the upper panel of the third column) erroneously reused images from panel 4a (the upper panel of the rightmost column);
Science
Science
fromNature
2 months ago

A 'time capsule for cells' stores the secret experiences of their past

Engineered TimeVaults capture and store cellular mRNA to continuously record past transcriptional activity, enabling retrospective study of cellular history and responses.
Science
fromwww.nature.com
1 month ago

Author Correction: Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

Extended Data Fig. 4d duplicated Fig. 2a and strains were partially misannotated; corrected figures are provided and do not change study results or conclusions.
Science
fromNature
2 months ago

Construction of complex and diverse DNA sequences using DNA three-way junctions - Nature

DNA writing remains limited by short oligo synthesis and two-way junction assembly methods, hindering affordable, scalable construction of large, complex synthetic DNA.
fromNature
2 months ago

Daily briefing: The human cells in our bodies that aren't genetically ours

A virus that sickens marine mammals has been detected in Arctic waters for the first time. Scientists used drones armed with petri dishes to collect samples of blow - the air and mucus whales expel from their blowholes - from whales in northern Norway. The team identified cetacean morbillivirus in samples from humpback whales ( Megaptera novaeangliae) and one sperm whale ( Physeter macrocephalus), though the humpbacks showed no symptoms of disease.
Science
Science
fromArs Technica
1 month ago

Tiny, 45 base long RNA can make copies of itself

A 45-base RNA ribozyme can self-replicate, supporting RNA-based origin-of-life scenarios where RNA carried both genetic information and catalytic functions.
Science
fromwww.scientificamerican.com
2 months ago

How long you live may depend much more on your genes than scientists thought

Heritability of human lifespan roughly doubles to about 50% when extrinsic mortality is removed, showing a stronger genetic influence on intrinsic aging.
Science
fromNature
2 months ago

RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity - Nature

Some immune systems inactivate tRNAs to impair viral protein synthesis, and certain Cas nucleases, like LshCas13a, can cleave tRNA anticodon loops.
[ Load more ]