#targeted-therapy

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#brd4 #transcription-regulation #cancer-treatment #protein-degradation #polymer-chemistry
Medicine
fromNews Center
1 week ago

Trashing Cancer's 'Undruggable' Proteins - News Center

Northwestern scientists developed protein-like polymers that direct cancer-driving proteins to cellular degradation machinery, causing cancer cell death and tumor growth inhibition.
Science
fromwww.scientificamerican.com
2 weeks ago

Cats' cancer genes show striking similarity to humans'

Feline cancers share genetic drivers with human (and dog) cancers, enabling potential targeted treatments, improved diagnostics for cats, and translational insights for human oncology.
Science
fromNews Center
1 month ago

New Underlying Mechanisms May Support Proper Transcriptional Regulation and Improve Targeted Therapies - News Center

BET proteins, particularly BRD4, regulate transcription initiation and elongation independently of bromodomains, with implications for targeted therapeutic development.
Science
fromNews Center
1 month ago

New Underlying Mechanisms May Support Proper Transcriptional Regulation and Improve - News Center

New mechanisms controlling transcription initiation and elongation involving BET family proteins were identified, revealing pathways that could enable improved targeted therapies for diseases including cancer.
fromenglish.elpais.com
4 months ago

Guided missiles targeting tumor cells open a new route to combat cancer

If more than half a century ago, science looked expectantly at the potential of chemotherapy to combat cancer; or 15 years ago, oncologists did the same with immunotherapy, which energized the immune system's own defenses to attack tumor cells; now the spotlight has turned to an innovative treatment that is reaping promising results: antibodydrug conjugates (ADCs), treatments that function like a Trojan horse, delivering chemotherapy to the interior of tumor cells to destroy them.
Medicine
Cancer
fromwww.theguardian.com
8 months ago

UK-wide drug trial hailed as a milestone' in leukaemia treatment

A UK trial found a chemotherapy-free treatment for leukaemia that improves outcomes for patients, suggesting a significant shift in treatment approaches.
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