The thymus is a critical organ for T cell development, where distinct cellular structures and compartments facilitate the differentiation and maturation of T cells, ensuring immune system functionality.
Thymocytes undergo a complex maturation process, moving through stages of double-negative and double-positive phases, involving V(D)J recombination, positive selection, and negative selection to ensure self-tolerance.
The compartmentalization of the thymus into medulla and cortex, along with the presence of unique structures like medullary Hassall's corpuscles, plays a key role in shaping T cell immunity.
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