After a strong debut against the Bears, rookie running back Isaac Guerendo left the game with a foot injury, later diagnosed as a sprain.
Coach Kyle Shanahan confirmed Guerendo's foot sprain but didn't specify his availability for the upcoming game against the Rams, as evaluations continue.
With injuries to key players like McCaffrey and Mason, Guerendo's standout performance with 78 rushing yards and two touchdowns illustrates his potential.
The 49ers face a crucial matchup against the Rams on Thursday, with Guerendo's status being a concern given the tight NFC West playoff race.
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