Mason rushed eight times for 65 yards and added one catch for nine yards before exiting the game with a shoulder injury in the second quarter.
Mason's exit was concerning for the 49ers, as he was showing promise as a breakout running back before the injury.
With Mason's departure, rookie Isaac Gurendo and veteran Deebo Samuel are expected to take over the running back responsibilities.
The team is waiting for updates on Mason's condition, as he was seen getting his shoulder checked out and is now questionable to return.
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