The NFL's expansion into Germany continues as San Francisco looks forward to potentially playing against the Indianapolis Colts, marking a milestone in international games.
With games previously held in Frankfurt and Munich, the 2025 season will be significant for the NFL as it hosts its first game in Berlin.
The anticipation of the 49ers' schedule highlights the importance of planning ahead for international games, which can disrupt regular preparation.
As part of their journey through the AFC South, the San Francisco 49ers have a unique chance to play internationally, making their games more diverse.
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