Recent research published in Science Advances indicates that females may have a unique advantage against cognitive decline due to the activation of genes on their second X chromosome. In studies with female mice, aging prompted these genes to express in the hippocampus, a key brain region for learning and memory. When a gene therapy was applied to enhance this gene expression, cognitive abilities improved, suggesting potential for therapies that leverage this resilience in females. experts assert that understanding this mechanism could lead to new treatments benefiting cognition for all genders.
The recent study suggests that the second X chromosome in female brains, previously deemed 'silent', plays a crucial role in protecting against cognitive decline.
Research indicates that gene expression from the usually inactive X chromosome in female mice's hippocampus could lead to enhanced cognitive resilience, challenging previous assumptions.
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