Hangovers manifest through various physical symptoms like pain and discomfort, but scientific understanding is limited due to lack of research funding. Studies highlight the toxic effects of alcohol’s byproduct, acetaldehyde, while examining neurological changes during intoxication. Research led by Professor Magdalena Sastre shows not only neuronal changes but also heightened brain inflammation and mitochondrial dysfunction during hangovers. Factors such as dehydration and sleep disturbances contribute to overall malaise. Understanding these mechanisms may illuminate broader implications for mental health and alcoholism.
We saw that it wasn't just neuronal changes that occurred during alcohol intoxication. When blood alcohol levels dropped to zero, when the hangover began, changes occurred that could sometimes be even higher.
A hangover may be the consequence of metabolizing alcohol into acetaldehyde, a compound that is 20 times more toxic than alcohol itself.
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