"People with major depressive disorder can see a rapid and lasting improvement after a single dose of the psychedelic drug dimethyltryptamine (DMT) when it is combined with psychotherapy, doctors have said. A small clinical trial involving 34 people found that psychedelic-assisted therapy prompted a swift reduction in depressive symptoms that endured long after the drug had worn off, with some still feeling the benefits six months later."
"Although preliminary, the results add to a growing body of evidence that psychedelic drugs, when coupled with psychotherapy, could help to alleviate depression in the millions of people worldwide who do not respond to existing antidepressants or therapies."
A small clinical trial with 34 participants compared a single 21.5mg intravenous infusion of dimethyltryptamine (DMT) against placebo, with psychotherapy provided to all participants and follow-up assessments. Participants receiving DMT showed a rapid and significant reduction in depressive symptoms compared with placebo on a standard depression questionnaire. Antidepressant effects were sustained for three to six months following the single session. DMT produces powerful, often mystical hallucinogenic experiences that can alter time perception and dissolve the sense of self. An estimated 100 million people worldwide have treatment-resistant depression that does not respond to at least two antidepressants.
Read at www.theguardian.com
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