"One variant is associated with greater weight loss from the powerful GLP-1 medications. Others are linked to an increased risk of side effects such as nausea."
"The genetic effect on weight loss is relatively small. 'I don't see this as something that clinicians are going to use' to inform their practice."
"'There's a number of factors that can influence weight loss, of which genetics is a subcomponent.' But he notes that the genetic association with side effects was more substantial."
"Next-generation weight-loss drugs mimic natural hormones that influence appetite and metabolism. In one study, participants taking semaglutide lost an average of 10% of their body weight."
Researchers identified genetic variants that explain variability in responses to obesity drugs. One variant is linked to greater weight loss from GLP-1 medications, while others increase side effects like nausea. The study involved nearly 28,000 23andMe users. Although the genetic impact on weight loss is small, the association with side effects is more significant. Next-generation obesity drugs mimic hormones that regulate appetite and metabolism, leading to varied weight loss outcomes among users.
Read at Nature
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