"But the days of lying awake in the middle of the night could finally be a thing of the past. Scientists from Kanazawa University in Japan have developed a drug that can 'reset' your body clock forward. Called Mic-628, the compound works by inducing a clock gene called Per1. This particular gene plays a key role in maintaining your circadian rhythm - the internal body clock that regulates the sleep-wake cycle."
"In tests on mice, a single oral dose of Mic-628 shortened the internal clock's readjustment period from seven days to just four. The findings suggest the compound may serve as a prototype 'smart drug' for managing jet lag or shift work. And it could be more effective than existing methods of trying to rearrange the body clock, such as light therapy or taking melatonin, according to the experts."
Researchers developed Mic-628, an oral compound that induces the Per1 clock gene to shift the circadian clock forward. In mice a single dose reduced the internal clock's readjustment from seven days to four, indicating faster phase advancement. The compound may function as a prototype 'smart drug' to manage jet lag and shift work and could outperform light therapy or melatonin. West-to-east travel presents greater circadian advance challenges and younger people experience worse jet lag. Safety and effectiveness require further animal and human testing. Dietary timing, such as large breakfasts and skipping dinner, may also influence jet-lag recovery.
Read at Mail Online
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