This study finds that the mediodorsal thalamus plays a critical role in adaptive decision-making by independently representing cueing and rule uncertainty, impacting the processing in the prefrontal cortex.
The research reveals that thalamic populations drive prefrontal reconfiguration when errors are appropriately attributed to changes in the environment, suggesting a dynamic interaction between these brain regions.
Behavioral switching was mechanistically dissected, showing that there exists a transthalamic pathway crucial for cingulate cortical error monitoring, which ultimately helps in reconfiguring executive control in the prefrontal cortex.
By providing a low-dimensional pathway for cortico-cortical communication, the thalamus demixes cortical signals, which enhances the brain's ability to adapt to complex decision-making environments.
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