A growing body of evidence suggests that, at least in a subset of individuals, Parkinson's disease originates in the gut before affecting the central nervous system.
Many people who get Parkinson's disease experience GI symptoms like constipation and nausea for years - even decades - prior to developing motor symptoms like difficulty walking or tremors.
The study sheds light on the way Parkinson's may develop and suggests that increased vigilance among those with upper GI mucosal damage may be warranted.
Damage is typically identified as ulcerations caused by the H. pylori bacterium, gastroesophageal reflux disease (GERD) and/or the use of non-steroidal anti-inflammatory drugs.
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