Innate immune pattern recognition receptors like Toll-like receptors (TLRs) are crucial for the immune response to infections. Myddosomes, particularly the constituent MyD88, form contacts with activated TLRs, demonstrating dynamic behavior in size and composition. These structures act as scaffolds for effector protein recruitment in the TLR pathways, where proteins regulate all effector responses. Myddosome assembly is observed during infection, with suggestions that the TLR signaling pathway is executed within the myddosome.
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