Organoids from adult stem cells are pivotal for modeling human physiology but lack the complex immune environments crucial for studying intestinal health and disease.
Current models can mimic epithelial functions, yet they cannot accurately represent tissue-specific immune compartments essential for understanding conditions like autoimmune diseases or cancer.
Recent advancements have been made by co-culturing organoids with immune cells, yet the challenge remains in developing organoids that integrate a competent mucosal lymphocyte compartment.
Our study introduces an intestinal immuno-organoid model that simulates tissue-resident lymphocytes, allowing for a more comprehensive exploration of intestinal immunity and disease.
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