In this study, we identified previously unknown hierarchical arrangements of haematopoietic stem cells (HSCs) within bone marrow niches, which are crucial for their regenerative capabilities.
Our findings reveal that high-level nitric oxide-generating (NOhi) HSCs are resistant to immune attack, indicating a novel immune privilege that contributes to long-term stem cell reconstitution.
The unique capillaries associated with NOhi HSCs, which feature ciliated endothelium and high CD200 expression, play a significant role in regulating the function and immune tolerance of these cells.
Understanding the interactions between stem cells and their niches is essential as it may enhance the efficacy of stem cell transplantation and immunotherapy strategies.
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