"It's never been done at this scale before and no one's ever put specific numbers to the amount of weight you'll put on, or to the amount that your cholesterol goes up," he says."
"It may be that one medication which is pretty bad for one person actually is pretty good for another one. I think that is the message, rather than naming and shaming certain drugs," he says."
Researchers pooled data from more than 150 randomized clinical trials encompassing over 58,000 patients, mostly from eight-week studies, to compare physical side effects across 30 antidepressants. The analysis quantified effects on weight, blood pressure, heart rate, cholesterol and other metabolic and cardiovascular measures, producing a ranked comparison of medications. Selective serotonin reuptake inhibitors (SSRIs) such as sertraline and fluoxetine generally showed fewer physical side effects. Older classes, including tricyclics like nortriptyline, were associated with larger cardiovascular effects, for example an average heart-rate increase of about 20 beats compared with some SSRIs. Typical weight changes were on the order of a few pounds.
Read at www.npr.org
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