Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature
Briefly

The experiments were not randomized, and the investigators were not blinded, which could introduce bias in the outcome assessment. Furthermore, no statistical methods were employed to predetermine the sample size, affecting the robustness and generalizability of the findings.
Human adipose tissue biopsies were collected from three independent studies, ensuring a diverse source of samples for analyzing insulin resistance based on rigorous inclusion and exclusion criteria.
The inclusion criteria for the MTSS study emphasized significant BMI loss and the exclusion of participants with chronic diseases, adding rigor to the data quality by reducing confounding variables.
Samples were snap-frozen immediately post-surgery to preserve the integrity of cellular and molecular analysis, a critical step for accurate downstream applications like snRNA-seq.
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