"Aging is inevitable, but how fast your cells age isn't set in stone. On a molecular level, biological age is measured using something called the epigenetic clock, which isn't tied to chronological age in calendar years. This clock measures chemical changes, such as DNA methylation patterns, and gauges a person's "youthfulness" or "agedness" based on their epigenome, the system that controls how our genes are expressed, irrespective of birth-certificate age."
"Exercise's geroprotective mechanisms don't rewrite your genetic script. Instead, they provide stage directions that help your genes outmaneuver oxidative stressors while shielding against mitochondrial damage and the wear-and-tear of senescence (growing older). Moderate-to-vigorous physical activity ( MVPA) sustains DNA stability in a "Goldilocks zone" that's just right for optimizing methylation-related enzymes. Too much methylation can silence protective genes, while too little may activate harmful ones. By nudging methylation"
Biological age is measured by the epigenetic clock, which gauges cellular youthfulness through chemical changes such as DNA methylation patterns independent of chronological age. Lifestyle choices including diet, exercise, and stress management can slow or even rewind epigenetic aging. Regular physical activity functions as a geroprotector by influencing the epigenome, delaying or reversing epigenetic aging and extending healthspan. Structured exercise training can induce epigenomic rejuvenation, particularly in blood and skeletal muscle. Exercise protects against oxidative stress, mitochondrial damage, and cellular senescence. Moderate-to-vigorous physical activity sustains DNA stability within a Goldilocks zone optimal for methylation-related enzymes.
Read at Psychology Today
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