Tottenham's Son Heung-min has been directly involved in 22 goals in his past 22 top-flight appearances, with 14 goals and eight assists.
Luton are on a club record run of scoring in 17 successive top-flight fixtures.
Spurs have won six of their past seven Premier League home fixtures, failing to keep a clean sheet in their last 10 home league matches.
A league-high 36% of Luton's points this season have come from goals in the final 10 minutes.
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