To change Worlds in Once Human, you must head to a Teleporter, use it via pressing the G key, and select a new World to move to.
You can change Worlds as much as you like, there is no restriction to this, which is nice to know you're able to freshen things up without limit.
Regardless of this though, you will keep hold of any items and gear that are in your inventory, so no need to worry about that when switching.
Changing Worlds does keep you in the same server so keep that in mind if you were looking to move off a PvP server for example, wanting a quieter life in a more PvE only location.
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