"After a series of experiments in mice, the team found that diet induced thermogenesis produced almost the same weight loss as constant exposure to five degrees Celsius around the clock. The study was conducted with BMB colleagues Aylin Güller, Marcus Rosendahl, and Natasa Stanic, and the results were published in the journal eLife."
"Researchers found that cutting two amino acids common in animal protein-methionine and cysteine-made mice burn significantly more energy. The boost in heat production was nearly as powerful as constant exposure to cold temperatures. The mice didn't eat less or exercise more; they simply generated more heat in their beige fat."
"Many scientists and drug companies are trying to find ways to make the body behave as if it is cold, triggering thermogenesis without ice baths or freezing temperatures. But obesity researchers Philip Ruppert and Jan-Wilhelm Kornfeld from the Department of Biochemistry and Molecular Biology at the University of Southern Denmark explored a different strategy."
Researchers at the University of Southern Denmark discovered that reducing two amino acids—methionine and cysteine—commonly found in animal protein significantly increases energy expenditure in mice. The mice generated substantially more heat through beige fat activation, producing weight loss effects nearly equivalent to continuous exposure to five-degree Celsius temperatures. Notably, this metabolic boost occurred without changes in eating behavior or physical activity levels. The findings suggest that dietary manipulation alone can activate the body's thermogenic mechanisms, offering a potential alternative to cold exposure or pharmaceutical interventions for triggering calorie-burning heat production.
Read at ScienceDaily
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