Research indicates that while Ozempic leads to a decrease in lean mass by around 10%, the reduction does not primarily stem from skeletal muscles. Instead, significant weight loss occurs in other tissues like the liver, which can decrease in size without losing function. The findings suggest that while muscle mass appears stable, muscle strength may still diminish, raising concerns about potential risks, especially for older adults. More extensive studies are necessary to understand the implications of these changes in humans more clearly.
If we want to really help the individuals who may be losing muscle mass, then we need to know that they're actually losing muscle mass.
Loss of mass in metabolically active organs, such as the liver, is expected as part of healthy weight loss.
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