The experiment was carried out in 10 participants with an inherited condition that causes extremely high LDL, or 'bad,' cholesterol levels.
While the lower doses didn't have much of an effect, the highest dose reduced LDL cholesterol by 55 percent in the single patient who received it. Meanwhile, two patients who got the next-highest dose saw reductions of 39 percent and 48 percent.
But no one has ever used gene editing to lower cholesterol in people before. 'This is a strategy that could be revolutionary,' said Karol Watson, a cardiologist at UCLA.
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