Marseille's hopes of a first home league win against PSG since November 2011 were raised when the away side had Lucas Beraldo sent off five minutes before the interval.
PSG coach Luis Enrique then withdrew captain Kylian Mbappe just after the hour mark and it was his replacement Ramos who made sure of the win five minutes from time.
The result means PSG end the weekend as they started it, 12 points clear of second-placed Brest, who won 1-0 at Lorient earlier on Sunday.
The biggest talking point on the night was the red card for Beraldo, the young Brazilian defender signed in January. He went shoulder-to-shoulder with Pierre-Emerick Aubameyang, knocking the attacker over just past halfway near the right touchline.
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