We're on the edge of the cliff and we have to move away from it, Josep Borrell, the EU's High Representative for Foreign Affairs and Security Policy, told Spanish radio station Onda Cero.
Neither the region nor the world can afford more war, Guterres said late on Sunday. Now is the time to defuse and de-escalate.
Further escalation is in no one's interests, Kremlin spokesman Dmitry Peskov said.
Tehran's retaliatory attack on Israel has increased fears of open warfare between nations.
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