Yoro has been ruled out for three months for a foot injury while Højlund will miss the next six weeks with a hamstring problem.
Yoro, according to a source, will stay with the squad for the remainder of the tour and undergo further tests after returning to Manchester on Sunday.
The news is a blow to manager Erik ten Hag, who blamed injuries for a miserable campaign last season which saw United finish eighth in the Premier League.
United were keen to bolster their defence before Yoro's injury, and their search is likely to step up now the Frenchman has been ruled out, with interest in players from Bayern Munich and Everton.
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