Manchester City is desperately hoping to secure just their second win in 14 games, facing a Leicester side struggling under Ruud van Nistelrooy's management.
Tottenham's fanbase may soon turn on manager Ange Postecoglou if they fail to secure victory against Wolves, with Spurs already languishing in 11th place.
Southampton faces an uphill battle to retain their Premier League status but showed signs of promise in their recent defeat against West Ham under Ivan Juric.
Crystal Palace, after a rocky start, appears to have stabilized their campaign, providing some assurance against Southampton's desperate fight for survival.
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