Recent research from the University of Cambridge has identified a gene mutation, DENND1B, which may contribute to weight loss struggles in some individuals. The mutation impairs the ability to resist food and is also present in Labrador retrievers, explaining their obesity susceptibility. Although its direct impact on BMI is minimal, DENND1B is part of a larger genetic landscape that collectively increases the risk of obesity. Additionally, DENND1B may have associations with childhood asthma and immune disorders, highlighting its broader health implications.
In people, the effect of DENND1B is very subtle - it makes about 0.01 of a BMI point's difference. This is a small effect size and just one of over 1,000 discovered genetic variations across the genome which can increase or decrease a person's tendency to weight gain.
DENND1B acts as a dimmer switch to change the brain's response to food. The mutation may also be linked to the development of childhood asthma and immune disorders.
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