The anti-inflammatory properties of glucocorticoids involve reprogramming macrophage mitochondrial metabolism to increase itaconate production, inhibiting the inflammatory response by interfering with pro-inflammatory cytokine production.
Glucocorticoids interact with the pyruvate dehydrogenase complex to accelerate the tricarboxylic acid (TCA) cycle in macrophages, enhancing anti-inflammatory effects by potentiating itaconate production.
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